1-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethylamine → Pyrimidine-5-carboxylic acid-(1-{1-[4-(4-chloro-2-fluoro-phenoxy)-phenyl]-ethylcarbamoyl}-cyclopropyl)-amide

HRID 1406334Notes

Reaction equation

HRID 1406334 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]([NH:9][C:10]2([C:13]([OH:15])=O)[CH2:12][CH2:11]2)=[O:8])[CH:4]=[N:3][CH:2]=1.[Cl:16][C:17]1[CH:32]=[CH:31][C:20]([O:21][C:22]2[CH:27]=[CH:26][C:25]([CH:28]([NH2:30])[CH3:29])=[CH:24][CH:23]=2)=[C:19]([F:33])[CH:18]=1>>[Cl:16][C:17]1[CH:32]=[CH:31][C:20]([O:21][C:22]2[CH:23]=[CH:24][C:25]([CH:28]([NH:30][C:13]([C:10]3([NH:9][C:7]([C:5]4[CH:4]=[N:3][CH:2]=[N:1][CH:6]=4)=[O:8])[CH2:11][CH2:12]3)=[O:15])[CH3:29])=[CH:26][CH:27]=2)=[C:19]([F:33])[CH:18]=1

Participants

3

Reactant 2

HCID 584879121-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethylamineHCID 594962911-[(Pyrimidine-5-carbonyl)-amino]cyclopropanecarboxylic acid

Product 1

HCID 25232240Pyrimidine-5-carboxylic acid-(1-{1-[4-(4-chloro-2-fluoro-phenoxy)-phenyl]-ethylcarbamoyl}-cyclopropyl)-amideYield 29%

Procedure

Analogously to Example (1e) the title compound was prepared from 1-[(pyrimidine-5-carbonyl)-amino]-cyclopropanecarboxylic acid and 1-[4-(4-chloro-2-fluoro-phenoxy)-phenyl]-ethylamine.

Sources & evidence

ORD record
ord-13df96a26a9844fc88a9de8c373d225f
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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