反应详情

温度

110 °C

4.9 g (40 mmol) of 4-methoxy-phenol and 4.4 ml (40 mmol) of 3,4-difluorobenzaldehyde were dissolved in 40 ml DMA and stirred in a microwave (CEM Explorer) for 15 minutes at 110° C., then filtered through basic Alox, washed with DMF and concentrated by rotary evaporation. The residue was separated through a KG column with a gradient (cyclohexane+10-25% ethyl acetate) and concentrated by rotary evaporation.

1. filtrationfiltered through basic Alox
2. washwashed with DMF
3. concentrationconcentrated by rotary evaporation
4. customThe residue was separated through a KG column with a gradient (cyclohexane+10-25% ethyl acetate)
5. concentrationconcentrated by rotary evaporation