Ammonia → 3-Fluoro-4-(4-methoxy-phenoxy)-benzylamine

HRID 1406336Notes

Reaction equation

HRID 1406336 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)[CH:5]=O.[NH3:19]>[Ni]>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)[CH2:5][NH2:19]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 286041023-Fluoro-4-(4-methoxy-phenoxy)-benzaldehyde

Product 1

HCID 289662543-Fluoro-4-(4-methoxy-phenoxy)-benzylamine

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Conditions

Temperature
35 °C

Procedure

73.9 mg (0.3 mmol) of 3-fluoro-4-(4-methoxy-phenoxy)-benzaldehyde are dissolved in 5 ml of methanolic ammonia, combined with Ra—Ni and shaken for about 9 hours at 35° C. and 3 bar H2 pressure.

Sources & evidence

ORD record
ord-d8b5367d71c94ce6a4b191e15f18e3dc
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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