Pyrrolidine → HCID 86658813, compound

Participants

Role	Name	HCID	Charge
Reactant	Pyrrolidine	HCID 31268	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
Reactant	HCID 86658814	HCID 86658814	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 86658813	HCID 86658813	—

Reaction Steps

1 g (4.1 mmol) of 3-(4-formyl-phenoxy)-benzoic acid were dissolved in 25 ml DMF and combined with 0.86 ml (4.95 mmol) of DIPEA and 1.32 g (4.1 mmol) of TBTU, stirred for 5 min at ambient temperature and then 0.29 g (4.1 mmol) of pyrrolidine were added. The mixture was stirred at ambient temperature, filtered through basic Alox, concentrated by rotary evaporation and purified by chromatography (silica gel column, dichloromethane with gradient of 0-10% methanol).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08916589B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-0e7e2ef3c54a4606be3a245ee1a05843
Source note	uspto-grants-2014_12