反应详情

温度

80 °C

138 mg (1 mmol) of 4-fluoroacetophenone were taken and 124 mg (1 mmol) of 4-methoxyphenol were dissolved in DMSO and added thereto, then 200 mg (1.45 mmol) of K2CO3 were added and the mixture was stirred for 8 h at 80° C., then for 6 h at 100° C., then for 3 h at 120° C. and for 3 h at 140° C. The reaction mixture was filtered through basic Alox, washed with DMF/methanol=9/1 and concentrated by rotary evaporation. The substance was purified by reversed-phase chromatography.

1. additionadded
2. waitfor 6 h at 100° C.
3. waitfor 3 h at 120° C.
4. waitfor 3 h at 140° C
5. filtrationThe reaction mixture was filtered through basic Alox
6. washwashed with DMF/methanol=9/1
7. concentrationconcentrated by rotary evaporation
8. customThe substance was purified by reversed-phase chromatography