Ammonia → HCID 58487893, compound

HRID 1406344Notes

Reaction equation

HRID 1406344 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[O:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[C:7]([F:13])[CH:6]=1.[H][H].[NH3:20]>[Ni]>[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:20])=[C:7]([F:13])[CH:6]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 86658815HCID 86658815, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58487893HCID 58487893, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Conditions

Temperature
35 °C

Procedure

148 mg (0.59 mmol) of 4-(2-chlorophenoxy)-2-fluorobenzaldehyde were dissolved in 10 ml of 7M methanolic ammonia and 50 mg Raney nickel were added. The mixture was shaken for 4 h at 35° C. and 3 bar hydrogen pressure. The catalyst was removed by suction filtering, the residue was evaporated down and purified by reversed-phase chromatography.

Workup

  1. customThe catalyst was removed by suction
  2. filtrationfiltering
  3. customthe residue was evaporated down
  4. custompurified by reversed-phase chromatography

Sources & evidence

ORD record
ord-07661aa39a114bd580657de55a963171
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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