Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 86658815 | HCID 86658815 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | HCID 58487893 | HCID 58487893 | — |
Reaction Steps
148 mg (0.59 mmol) of 4-(2-chlorophenoxy)-2-fluorobenzaldehyde were dissolved in 10 ml of 7M methanolic ammonia and 50 mg Raney nickel were added. The mixture was shaken for 4 h at 35° C. and 3 bar hydrogen pressure. The catalyst was removed by suction filtering, the residue was evaporated down and purified by reversed-phase chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08916589B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-07661aa39a114bd580657de55a963171 |
|---|
| Source note | uspto-grants-2014_12 |
|---|
