Hydroxylamine → HCID 86658817, compound

HRID 1406353Notes

Reaction equation

HRID 1406353 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])[CH:5]=[CH:4][C:3]=1[C:16](=O)[CH3:17].[NH2:19][OH:20]>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])[CH:5]=[CH:4][C:3]=1[C:16](=[N:19][OH:20])[CH3:17]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 64335498HCID 64335498, compound

Product 1

HCID 86658817HCID 86658817, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.4 g (8.54 mmol) of 1-[2-chloro-4-(2-chloro-phenoxy)-phenyl]-ethanone and 0.76 mL hydroxylamine solution (50% in water) in 60 mL ethanol was refluxed for 24 hours. Then the mixture was evaporated to dryness and the residue was purified by chromatography (silica gel column, methylene chloride).

Workup

  1. temperaturewas refluxed for 24 hours
  2. customThen the mixture was evaporated to dryness
  3. customthe residue was purified by chromatography (silica gel column, methylene chloride)

Sources & evidence

ORD record
ord-b46822da663f47b1b76d6e3b673cd153
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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