Potassium Carbonate → HCID 66790347, compound

HRID 1406355Notes

Reaction equation

HRID 1406355 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[Cl:11][C:12]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=1[OH:20].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[Cl:1][C:2]1[CH:9]=[C:8]([O:20][C:13]2[CH:14]=[CH:15][C:16]([O:18][CH3:19])=[CH:17][C:12]=2[Cl:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 874592-Chloro-4-methoxyphenolHCID 1090002-Chloro-4-fluorobenzonitrile

Product 1

HCID 66790347HCID 66790347, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
120 °C

Procedure

A solution of 3.0 g (19.28 mmol) of 2-chloro-4-fluorobenzonitrile and 3.06 g (19.28 mmol) of 2-chloro-4-methoxyphenol in 77 mL DMSO was combined with 5.32 g (38.57 mmol) of potassium carbonate and stirred for 2 h at 120° C. Then the mixture was evaporated to dryness in vacuo, the residue was taken up in dichloromethane and washed once with semisaturated potassium carbonate solution and twice with water. The organic phase was dried on sodium sulphate and evaporated down.

Workup

  1. customThen the mixture was evaporated to dryness in vacuo
  2. washwashed once with semisaturated potassium carbonate solution and twice with water
  3. customThe organic phase was dried on sodium sulphate
  4. customevaporated down

Sources & evidence

ORD record
ord-42c319156c464da28c74a785af452827
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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