反应详情

温度

100 °C

A solution of 666 μL (5.52 mmol) of 4-fluoroacetophenone and 883 mg (5.52 mmol) of 4-(difluoromethoxy)phenol in 10 mL DMSO was combined with 1.91 g (13.78 mmol) of potassium carbonate and stirred overnight at 100° C. The reaction mixture was poured onto 250 mL semisaturated sodium chloride solution and extracted twice with tert-butylmethylether. The organic phase was dried and evaporated down. The residue was purified by chromatography (silica gel, petroleum ether/ethyl acetate).

1. additionThe reaction mixture was poured onto 250 mL
2. extractionextracted twice with tert-butylmethylether
3. customThe organic phase was dried
4. customevaporated down
5. customThe residue was purified by chromatography (silica gel, petroleum ether/ethyl acetate)