Hydroxylamine → HCID 86658821, compound

HRID 1406365Notes

Reaction equation

HRID 1406365 reaction equation
[F:1][CH:2]([F:20])[O:3][C:4]1[CH:19]=[CH:18][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=O)[CH3:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1.[NH2:21][OH:22]>C(O)C>[F:1][CH:2]([F:20])[O:3][C:4]1[CH:19]=[CH:18][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=[N:21][OH:22])[CH3:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 66789463HCID 66789463, compound

Product 1

HCID 86658821HCID 86658821, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1.37 g (4.92 mmol) of 1-[4-(4-difluoromethoxy-phenoxy)-phenyl]-ethanone and 1.16 mL hydroxylamine solution (50% in water) in 5 mL ethanol was refluxed for 3 hours. Then the mixture was concentrated and evaporated down several times with ethanol, and the residue was purified by chromatography (silica gel column, petroleum ether/ethyl acetate).

Workup

  1. temperaturewas refluxed for 3 hours
  2. concentrationThen the mixture was concentrated
  3. customevaporated down several times with ethanol
  4. customthe residue was purified by chromatography (silica gel column, petroleum ether/ethyl acetate)

Sources & evidence

ORD record
ord-94b9620ebbcc4851973e0d1568396df2
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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