反应详情

A mixture of 1.37 g (4.92 mmol) of 1-[4-(4-difluoromethoxy-phenoxy)-phenyl]-ethanone and 1.16 mL hydroxylamine solution (50% in water) in 5 mL ethanol was refluxed for 3 hours. Then the mixture was concentrated and evaporated down several times with ethanol, and the residue was purified by chromatography (silica gel column, petroleum ether/ethyl acetate).

1. temperaturewas refluxed for 3 hours
2. concentrationThen the mixture was concentrated
3. customevaporated down several times with ethanol
4. customthe residue was purified by chromatography (silica gel column, petroleum ether/ethyl acetate)