HCID 86658821, compound → 1-[4-(4-Difluoromethoxy-phenoxy)-phenyl]-ethylamine

HRID 1406366Notes

Reaction equation

HRID 1406366 reaction equation
[F:1][CH:2]([F:21])[O:3][C:4]1[CH:20]=[CH:19][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=[N:17]O)[CH3:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1.[H][H]>N.[Ni]>[F:1][CH:2]([F:21])[O:3][C:4]1[CH:20]=[CH:19][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]([NH2:17])[CH3:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 86658821HCID 86658821, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 584879101-[4-(4-Difluoromethoxy-phenoxy)-phenyl]-ethylamine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 222AmmoniaSolvent

Procedure

1.35 g (4.60 mmol) of 1-[4-(4-difluoromethoxy-phenoxy)-phenyl]-ethanone-oxime were dissolved in 50 ml of 7M methanolic ammonia, then combined with 100 mg Raney nickel. The mixture was shaken overnight at RT and 50 psi hydrogen pressure. The catalyst was removed by suction filtering and the filtrate was evaporated down.

Workup

  1. customThe catalyst was removed by suction
  2. filtrationfiltering
  3. customthe filtrate was evaporated down

Sources & evidence

ORD record
ord-7e8496d483644c6e97c87d12ee6f25f7
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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