HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86658821, compound → 1-[4-(4-Difluoromethoxy-phenoxy)-phenyl]-ethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86658821 | HCID 86658821 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 1-[4-(4-Difluoromethoxy-phenoxy)-phenyl]-ethylamine | HCID 58487910 | — |
Reaction Steps
1.35 g (4.60 mmol) of 1-[4-(4-difluoromethoxy-phenoxy)-phenyl]-ethanone-oxime were dissolved in 50 ml of 7M methanolic ammonia, then combined with 100 mg Raney nickel. The mixture was shaken overnight at RT and 50 psi hydrogen pressure. The catalyst was removed by suction filtering and the filtrate was evaporated down.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916589B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-7e8496d483644c6e97c87d12ee6f25f7 |
| Source note | uspto-grants-2014_12 |