Cyanoacetic acid → HCID 25231709, compound

HRID 1406375Notes

Reaction equation

HRID 1406375 reaction equation
[C:1]([CH2:3][C:4]([OH:6])=O)#[N:2].[CH3:7][O:8][C:9]1[CH:29]=[CH:28][C:12]([O:13][C:14]2[CH:27]=[CH:26][C:17]([CH2:18][NH:19][C:20]([C:22]3([NH2:25])[CH2:24][CH2:23]3)=[O:21])=[CH:16][CH:15]=2)=[C:11]([C:30]([F:33])([F:32])[F:31])[CH:10]=1>>[CH3:7][O:8][C:9]1[CH:29]=[CH:28][C:12]([O:13][C:14]2[CH:27]=[CH:26][C:17]([CH2:18][NH:19][C:20]([C:22]3([NH:25][C:4](=[O:6])[CH2:3][C:1]#[N:2])[CH2:23][CH2:24]3)=[O:21])=[CH:16][CH:15]=2)=[C:11]([C:30]([F:31])([F:32])[F:33])[CH:10]=1

Participants

3

Reactant 2

HCID 9740Cyanoacetic acidHCID 67448480HCID 67448480, compound

Product 1

HCID 25231709HCID 25231709, compound

Procedure

Prepared analogously to Example 85b) starting from cyanoacetic acid and 1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide (from 85a). In addition, the residue was finally purified by chromatography (reversed phase).

Workup

  1. customPrepared analogously to Example 85b)
  2. customIn addition, the residue was finally purified by chromatography (reversed phase)

Sources & evidence

ORD record
ord-89cab3046aa14502bdcba557994620ed
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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