反应详情

68 μL (0.48 mmol) of TEA and 57 mg (0.19 mmol) of TBTU were added to a solution of 23 mg (0.16 mmol) of 6-fluoro-nicotinic acid in 2 mL DMF and the mixture was stirred for 5 min at RT. Then 80 mg (0.16 mmol) of 1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide-trifluoroacetic acid salt (from 85a) was added and the mixture was stirred for 2 h at ambient temperature. A further 57 mg (0.19 mmol) of TBTU, 68 μL (0.48 mmol) of TEA and 23 mg (0.16 mmol) of 6-fluoro-nicotinic acid were added and the mixture was stirred overnight at RT. The reaction mixture was purified by chromatography (reversed phase).

1. stirringthe mixture was stirred for 2 h at ambient temperature
2. stirringthe mixture was stirred overnight at RT
3. customThe reaction mixture was purified by chromatography (reversed phase)