Thionyl Chloride → HCID 86660376, compound

HRID 1406439Notes

Reaction equation

HRID 1406439 reaction equation
[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([Cl:14])[CH:3]=1.S(Cl)([Cl:17])=O>ClCCl>[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6]([Cl:17])=[O:7])=[C:4]([Cl:14])[CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22631420HCID 22631420, compound

Product 1

HCID 86660376HCID 86660376, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 4-amino-2-chloro-5-nitro-benzoic acid (2.60 g, 12.0 mmol) in 200 mL dichloromethane with 20 mL thionyl chloride was refluxed for 4 h, cooled to ambient temperature, filtrated and concentrated to dryness i.vac. The residue was further reacted without further purification.

Workup

  1. temperaturewas refluxed for 4 h
  2. filtrationfiltrated
  3. concentrationconcentrated to dryness i.vac
  4. customThe residue was further reacted without further purification

Sources & evidence

ORD record
ord-bb973ba87c754668b93f01d084e75fc4
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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