2-Amino-4,5-dimethyl-1,3-thiazole → HCID 47098616, compound

HRID 1406440Notes

Reaction equation

HRID 1406440 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[NH2:14][C:15]1[S:16][C:17]([CH3:21])=[C:18]([CH3:20])[N:19]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN(C=O)C>[CH3:20][C:18]1[N:19]=[C:15]([NH:14][C:6](=[O:8])[C:5]2[CH:9]=[CH:10][C:2]([NH2:1])=[C:3]([N+:11]([O-:13])=[O:12])[CH:4]=2)[S:16][C:17]=1[CH3:21]

Participants

5

Reactant 3

HCID 732382-Amino-4,5-dimethyl-1,3-thiazoleHCID 74115Benzoic acid, 4-amino-3-nitro-HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Product 1

HCID 47098616HCID 47098616, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to example 3c with 4-amino-3-nitro-benzoic acid and 2-amino-4,5-dimethyl-thiazole using TBTU and TEA in DMF.

Sources & evidence

ORD record
ord-d3f439e1c6594be0b0adb0a705a9e105
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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