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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1406459Generated: October 31, 2026

Diisopropylcarbodiimide → Ethyl 2-(2,6-dichlorophenylamino)-6-fluoro-1-methyl-1H-benzimidazole-5-carboxylate

https://huagongshe.com/reaction/1406459

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylcarbodiimideHCID 12734—
ReactantEthyl 5-(3-(2,6-dichlorophenyl)thioureido)-2-fluoro-4-(methylamino)benzoateHCID 86660379—
SolventAcetonitrileHCID 6342—
ProductEthyl 2-(2,6-dichlorophenylamino)-6-fluoro-1-methyl-1H-benzimidazole-5-carboxylateHCID 67229860—

Reaction Steps

Prepared analogously to example 127e from 5-[3-(2,6-dichloro-phenyl)-thioureido]-2-fluoro-4-methylamino-benzoic acid ethyl ester and DIC in acetonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916599B2
Source datasetuspto-grants-2014_12
ORD IDord-d104e3ca7b2c4a72bacf0496df5e23bb
Source noteuspto-grants-2014_12