Diisopropylcarbodiimide → Ethyl 2-(2,6-dichlorophenylamino)-6-fluoro-1-methyl-1H-benzimidazole-5-carboxylate

HRID 1406459Notes

Reaction equation

HRID 1406459 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[C:9]([NH:11][C:12]([NH:14][C:15]2[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:22])=S)[C:8]([NH:23][CH3:24])=[CH:7][C:6]=1[F:25])[CH3:2].CC(C)N=C=NC(C)C>C(#N)C>[CH2:1]([O:3][C:4]([C:5]1[C:6]([F:25])=[CH:7][C:8]2[N:23]([CH3:24])[C:12]([NH:14][C:15]3[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:22])=[N:11][C:9]=2[CH:10]=1)=[O:26])[CH3:2]

Participants

4

Reactant 2

HCID 12734DiisopropylcarbodiimideHCID 86660379Ethyl 5-(3-(2,6-dichlorophenyl)thioureido)-2-fluoro-4-(methylamino)benzoate

Product 1

HCID 67229860Ethyl 2-(2,6-dichlorophenylamino)-6-fluoro-1-methyl-1H-benzimidazole-5-carboxylate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared analogously to example 127e from 5-[3-(2,6-dichloro-phenyl)-thioureido]-2-fluoro-4-methylamino-benzoic acid ethyl ester and DIC in acetonitrile.

Sources & evidence

ORD record
ord-d104e3ca7b2c4a72bacf0496df5e23bb
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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