HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Amino-2-fluoro-5-nitrobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Acetamido-2-fluoro-5-nitrobenzoic acid | HCID 67230302 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Amino-2-fluoro-5-nitrobenzoic acid | HCID 59785337 | — |
Reaction Steps
A solution of the product obtained at 142c (5.95 g, 24.6 mmol) in 100 mL dioxane and 100 mL half-conc. hydrochloric acid was heated to 110° C. for 1.5 h. The mixture was cooled in an ice bath, filtered and washed with water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916599B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-f1baab28c38644aa9a413064f0e6bf4e |
| Source note | uspto-grants-2014_12 |