Hydrochloric Acid → 4-Amino-2-fluoro-5-nitrobenzoic acid

HRID 1406468Notes

Reaction equation

HRID 1406468 reaction equation
C([NH:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:17])[CH:6]=1)(=O)C.Cl>O1CCOCC1>[NH2:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:17])[CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 672303024-Acetamido-2-fluoro-5-nitrobenzoic acid

Product 1

HCID 597853374-Amino-2-fluoro-5-nitrobenzoic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of the product obtained at 142c (5.95 g, 24.6 mmol) in 100 mL dioxane and 100 mL half-conc. hydrochloric acid was heated to 110° C. for 1.5 h. The mixture was cooled in an ice bath, filtered and washed with water.

Workup

  1. temperatureThe mixture was cooled in an ice bath
  2. filtrationfiltered
  3. washwashed with water

Sources & evidence

ORD record
ord-f1baab28c38644aa9a413064f0e6bf4e
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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