Ethanol → Ethyl 4-amino-2-fluoro-5-nitrobenzoate

HRID 1406479Notes

Reaction equation

HRID 1406479 reaction equation
[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:14])[CH:3]=1.[CH2:15]([OH:17])[CH3:16]>>[CH2:15]([O:17][C:6](=[O:7])[C:5]1[CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:2]([NH2:1])=[CH:3][C:4]=1[F:14])[CH3:16]

Participants

3

Reactant 2

HCID 702EthanolHCID 866603804-Amino-5-nitro-2-fluoro-benzoyl chloride

Product 1

HCID 59529828Ethyl 4-amino-2-fluoro-5-nitrobenzoateYield 89%

Procedure

A solution of the product obtained at 149e (1.4 g, 6.4 mmol) in 50 mL ethanol was heated to reflux for 2 h. The mixture was filtered and the filtrate concentrated i.vac. The residue is reacted without any further purification. Yield: 89%.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 2 h
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate concentrated i.vac
  5. customThe residue is reacted without any further purification

Sources & evidence

ORD record
ord-bb09c702cf3849beb02397cf6bbc8c08
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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