Ethyl 4-amino-2-fluoro-5-nitrobenzoate → Ethyl 4,5-diamino-2-fluorobenzoate

HRID 1406480Notes

Reaction equation

HRID 1406480 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([NH2:14])=[CH:7][C:6]=1[F:15])[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([NH2:11])[C:8]([NH2:14])=[CH:7][C:6]=1[F:15])[CH3:2]

Participants

4

Reactant 1

HCID 59529828Ethyl 4-amino-2-fluoro-5-nitrobenzoate

Product 1

HCID 67230558Ethyl 4,5-diamino-2-fluorobenzoate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Prepared analogously to example 1b by hydrogenation of 4-amino-5-nitro-2-fluoro-benzoic acid ethyl ester using palladium/charcoal 10% in methanol.

Sources & evidence

ORD record
ord-8e42cc9d319c4f1e9ddf91216aa9a661
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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