Ethanol → Ethyl 2,4-difluoro-5-nitrobenzoate

HRID 1406481Notes

Reaction equation

HRID 1406481 reaction equation
[CH2:1]([OH:3])[CH3:2].[F:4][C:5]1[CH:13]=[C:12]([F:14])[C:11]([N+:15]([O-:17])=[O:16])=[CH:10][C:6]=1[C:7](Cl)=[O:8]>C1COCC1>[CH2:1]([O:3][C:7](=[O:8])[C:6]1[CH:10]=[C:11]([N+:15]([O-:17])=[O:16])[C:12]([F:14])=[CH:13][C:5]=1[F:4])[CH3:2]

Participants

4

Reactant 2

HCID 702EthanolHCID 183144972,4-Difluoro-5-nitrobenzoyl chloride

Product 1

HCID 22330120Ethyl 2,4-difluoro-5-nitrobenzoate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethanol (1.50 mL, 26.0 mmol) was added to a stirred mixture of 2,4-difluoro-5-nitro-benzoyl chloride (5.0 g, 22.6 mmol) and TEA (3.50 mL, 25.2 mmol) in 50 mL THF. After 30 min of stirring the precipitate was filtered and washed with THF. The filtrate was concentrated i.vac.

Workup

  1. filtrationwas filtered
  2. washwashed with THF
  3. concentrationThe filtrate was concentrated i.vac

Sources & evidence

ORD record
ord-78c9254a4168491cb0808d59a89414b8
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

Loading…