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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1406483Generated: October 30, 2026

Ethyl 2-fluoro-4-(methylamino)-5-nitrobenzoate → 5-Amino-2-fluoro-4-methylamino-benzoic acid ethyl ester

https://huagongshe.com/reaction/1406483

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-fluoro-4-(methylamino)-5-nitrobenzoateHCID 59529818—
CatalystNickelHCID 935—
SolventTetrahydrofuranHCID 8028—
Product5-Amino-2-fluoro-4-methylamino-benzoic acid ethyl esterHCID 67230046—

Reaction Steps

Prepared analogously to example 14b by hydrogenation of 2-fluoro-4-methylamino-5-nitro-benzoic acid ethyl ester using Raney nickel in THF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916599B2
Source datasetuspto-grants-2014_12
ORD IDord-1e49f3ac487c43ec951cc4bd2913e36a
Source noteuspto-grants-2014_12