HCID 59529818, compound → 5-Amino-2-fluoro-4-methylamino-benzoic acid ethyl ester

HRID 1406483Notes

Reaction equation

HRID 1406483 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([NH:14][CH3:15])=[CH:7][C:6]=1[F:16])[CH3:2]>[Ni].C1COCC1>[CH2:1]([O:3][C:4](=[O:17])[C:5]1[CH:10]=[C:9]([NH2:11])[C:8]([NH:14][CH3:15])=[CH:7][C:6]=1[F:16])[CH3:2]

Participants

4

Reactant 1

HCID 59529818HCID 59529818, compound

Product 1

HCID 672300465-Amino-2-fluoro-4-methylamino-benzoic acid ethyl ester

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 14b by hydrogenation of 2-fluoro-4-methylamino-5-nitro-benzoic acid ethyl ester using Raney nickel in THF.

Sources & evidence

ORD record
ord-1e49f3ac487c43ec951cc4bd2913e36a
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

Loading…