O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 178481226, compound

HRID 1406486Notes

Reaction equation

HRID 1406486 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH:9][C:10]1[N:14]([CH3:15])[C:13]2[CH:16]=[CH:17][C:18]([C:20](O)=[O:21])=[CH:19][C:12]=2[N:11]=1.Cl.[F:24][C:25]([F:34])([F:33])[C@H:26]1[CH2:31][CH2:30][C@H:29]([NH2:32])[CH2:28][CH2:27]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN(C=O)C>[F:24][C:25]([F:33])([F:34])[C@H:26]1[CH2:27][CH2:28][C@H:29]([NH:32][C:20]([C:18]2[CH:17]=[CH:16][C:13]3[N:14]([CH3:15])[C:10]([NH:9][C:3]4[C:4]([F:8])=[CH:5][CH:6]=[CH:7][C:2]=4[F:1])=[N:11][C:12]=3[CH:19]=2)=[O:21])[CH2:30][CH2:31]1

Participants

5

Reactant 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 67230051HCID 67230051, compoundHCID 178479257HCID 178479257, compound

Product 1

HCID 178481226HCID 178481226, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to example 3c from 2-(2,6-difluoro-phenylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid and trans-4-trifluoromethyl-cyclohexylamine hydrochloride with TBTU in DMF.

Sources & evidence

ORD record
ord-6c5ee080b5474de898dbfc5a82e2588f
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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