HCID 86660383, compound → HCID 86660382, compound

HRID 1406494Notes

Reaction equation

HRID 1406494 reaction equation
[C:1]([O:5][C:6](=[O:31])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18](=[O:27])[NH:19][C:20]2[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][N:21]=2)=[CH:14][C:13]=1[N+:28]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>CO.C1COCC1>[C:1]([O:5][C:6](=[O:31])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18](=[O:27])[NH:19][C:20]2[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][N:21]=2)=[CH:14][C:13]=1[NH2:28])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 86660383HCID 86660383, compound

Product 1

HCID 86660382HCID 86660382, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 1b by hydrogenation of {3-[4-(4-chloro-pyridin-2-ylcarbamoyl)-2-nitro-phenylamino]-propyl}-carbamic acid tert.-butyl ester using Pt/charcoal 5% in methanol and THF.

Sources & evidence

ORD record
ord-e920daebf2fc448fbdc0389613c44f9e
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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