HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 2-(2,6-Dichloro-phenylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid (4,4-dimethyl-cyclohexyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 4,4-Dimethylcyclohexanamine hydrochloride | HCID 24191928 | — |
| Reactant | 2-(2,6-dichloro-phenylamino)-1-methyl-1H-benzimidazole-6-carboxylic acid | HCID 68519287 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(2,6-Dichloro-phenylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid (4,4-dimethyl-cyclohexyl)-amide | HCID 58562300 | — |
Reaction Steps
Prepared analogously to example 3c from 2-(2,6-dichloro-phenylamino)-1-methyl-1H-benzimidazole-6-carboxylic acid, 4,4-dimethyl-cyclohexylamine hydrochloride, TBTU and NMM in DMF; mp: 189-190° C., Rf value: 0.56 (silica gel; petrol ether/ethyl acetate=2:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916599B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-4199d8d406f14029be7940b71db40fda |
| Source note | uspto-grants-2014_12 |