Methylamine → HCID 7406921, compound

HRID 1406505Notes

Reaction equation

HRID 1406505 reaction equation
[CH3:1][NH2:2].[Br:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:22])[C:12]2[CH:17]=[CH:16][C:15](F)=[C:14]([N+:19]([O-:21])=[O:20])[CH:13]=2)=[CH:6][CH:5]=1>>[Br:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:22])[C:12]2[CH:17]=[CH:16][C:15]([NH:2][CH3:1])=[C:14]([N+:19]([O-:21])=[O:20])[CH:13]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 3651415HCID 3651415, compound

Product 1

HCID 7406921HCID 7406921, compound

Conditions

Temperature
60 °C

Procedure

40 mL liquid methylamine was added to a stirred mixture of N-(4-bromo-phenyl)-4-fluoro-3-nitro-benzamide (1.5 g, 4.4 mmol) in a pressure tube. The mixture was stirred for 20 h at 60° C. The mixture was cooled and concentrated i.vac. The residue was taken up in ethyl acetate, filtered with celite and silica gel and dried.

Workup

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated i.vac
  3. filtrationfiltered with celite and silica gel
  4. customdried

Sources & evidence

ORD record
ord-943d1ff002734d849193c702a89dd74e
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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