Benzoic acid, 4-amino-2,3-difluoro-5-nitro-, methyl ester → Methyl 4,5-diamino-2,3-difluorobenzoate

HRID 1406519Notes

Reaction equation

HRID 1406519 reaction equation
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([F:15])[C:3]=1[F:16]>CO.ClCCl.[Pd]>[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([F:15])[C:3]=1[F:16]

Participants

5

Reactant 1

HCID 2759749Benzoic acid, 4-amino-2,3-difluoro-5-nitro-, methyl ester

Product 1

HCID 86651263Methyl 4,5-diamino-2,3-difluorobenzoate

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to example 1b by hydrogenation of methyl 4-amino-2,3-difluoro-5-nitrobenzoate using palladium/charcoal 10% in methanol and dichloromethane.

Sources & evidence

ORD record
ord-53c3acf550eb48bca230c7a5964b64e2
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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