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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1406524Generated: November 1, 2026

Methylamine → Ethyl 2-fluoro-4-(methylamino)-5-nitrobenzoate

https://huagongshe.com/reaction/1406524

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethylamineHCID 6329—
ReactantEthyl 2,4-difluoro-5-nitrobenzoateHCID 22330120—
SolventTetrahydrofuranHCID 8028—
ProductEthyl 2-fluoro-4-(methylamino)-5-nitrobenzoateHCID 59529818—

Reaction Steps

Prepared analogously to example 156b from 2,4-difluoro-5-nitro-benzoic acid ethyl ester and 2 M methylamine (solution in THF) in THF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916599B2
Source datasetuspto-grants-2014_12
ORD IDord-80443c2b27844accaa30204349fc74af
Source noteuspto-grants-2014_12