HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,5-Dimethylpyridin-2-amine → 2-(2,6-Dichlorophenylamino)-N-(4,5-dimethylpyridin-2-yl)-6-fluoro-1-methyl-1H-benzimidazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,5-Dimethylpyridin-2-amine | HCID 12404013 | — |
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | Ethyl 2-(2,6-dichlorophenylamino)-6-fluoro-1-methyl-1H-benzimidazole-5-carboxylate | HCID 67229860 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 2-(2,6-Dichlorophenylamino)-N-(4,5-dimethylpyridin-2-yl)-6-fluoro-1-methyl-1H-benzimidazole-5-carboxamide | HCID 58562291 | — |
Reaction Steps
Prepared analogously to example 131f from ethyl 2-(2,6-dichlorophenylamino)-6-fluoro-1-methyl-1H-benzimidazole-5-carboxylate, 2 M trimethyl aluminium solution in hexane and 4,5-dimethylpyridin-2-amine in THF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916599B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-24c9a9f8dfc94f2a9ee46af08ef645ce |
| Source note | uspto-grants-2014_12 |