Diisopropylcarbodiimide → Ethyl 2-(2,6-dichlorophenylamino)-6-fluoro-1-methyl-1H-benzimidazole-5-carboxylate

HRID 1406531Notes

Reaction equation

HRID 1406531 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10](=S)[NH:11][C:12]1[C:13]([NH:24][CH3:25])=[CH:14][C:15]([F:23])=[C:16]([CH:22]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18].CC(C)N=C=NC(C)C>C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]1[N:24]([CH3:25])[C:13]2[CH:14]=[C:15]([F:23])[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:22][C:12]=2[N:11]=1

Participants

4

Reactant 2

HCID 12734DiisopropylcarbodiimideHCID 86660379Ethyl 5-(3-(2,6-dichlorophenyl)thioureido)-2-fluoro-4-(methylamino)benzoate

Product 1

HCID 67229860Ethyl 2-(2,6-dichlorophenylamino)-6-fluoro-1-methyl-1H-benzimidazole-5-carboxylate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared analogously to example 127e from ethyl 5-(3-(2,6-dichlorophenyl)-thioureido)-2-fluoro-4-(methylamino)-benzoate and DIC in acetonitrile.

Sources & evidence

ORD record
ord-64738a3cc0b04115ab3323e1e9956706
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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