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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1406535Generated: October 30, 2026

Ammonia → Ethyl 4-amino-2-fluoro-5-nitrobenzoate

https://huagongshe.com/reaction/1406535

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmoniaHCID 222—
ReactantEthyl 2,4-difluoro-5-nitrobenzoateHCID 22330120—
SolventTetrahydrofuranHCID 8028—
ProductEthyl 4-amino-2-fluoro-5-nitrobenzoateHCID 59529828—

Reaction Steps

Prepared analogously to example 156b from 2,4-difluoro-5-nitrobenzoic acid-ethyl ester and conc. ammonia (aq) in THF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916599B2
Source datasetuspto-grants-2014_12
ORD IDord-eb2d27f6d2de4226bffd615fc3c1ec10
Source noteuspto-grants-2014_12