Ammonia → Ethyl 4-amino-2-fluoro-5-nitrobenzoate

HRID 1406535Notes

Reaction equation

HRID 1406535 reaction equation

[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8](F)=[CH:7][C:6]=1[F:15])[CH3:2].[NH3:17]>C1COCC1>[NH2:17][C:8]1[C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:16])=[C:6]([F:15])[CH:7]=1

Participants

4

Reactant 2

HCID 222Ammonia

HCID 22330120Ethyl 2,4-difluoro-5-nitrobenzoate

Product 1

HCID 59529828Ethyl 4-amino-2-fluoro-5-nitrobenzoate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 156b from 2,4-difluoro-5-nitrobenzoic acid-ethyl ester and conc. ammonia (aq) in THF.

Sources & evidence

ORD record: ord-eb2d27f6d2de4226bffd615fc3c1ec10
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08916599B2

Reaction notes

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