Dimethylformamide → HCID 178521146, compound

HRID 1406537Notes

Reaction equation

HRID 1406537 reaction equation
[F:1][C:2]([F:13])([F:12])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9](O)=[O:10])[CH2:5][CH2:4]1.S(Cl)([Cl:16])=O.CN(C=O)C>ClCCl>[F:1][C:2]([F:13])([F:12])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([Cl:16])=[O:10])[CH2:5][CH2:4]1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 178525710HCID 178525710, compound

Product 1

HCID 178521146HCID 178521146, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of trans-4-trifluoromethyl-cyclohexyl-carboxylic acid (10.7 g, 54.3 mmol) and thionylchloride (10 mL, 138 mmol) in 100 mL dichloromethane with 200 μL DMF was refluxed for 2 h. The mixture was concentrated i.vac. and triturated with dichloromethane. The residue was reacted without further purification.

Workup

  1. temperaturewas refluxed for 2 h
  2. concentrationThe mixture was concentrated i.vac
  3. customand triturated with dichloromethane
  4. customThe residue was reacted without further purification

Sources & evidence

ORD record
ord-61ff3c8d1bc141639edcb36c8fa20884
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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