反应详情

温度

0 °C

Benzylamine (7.6 mL, 69 mmol) in 30 mL THF was added to ethyl 2,4-difluoro-5-nitro-benzoate (16.0 g, 69 mmol) in 270 mL THF with TEA (19.7 mL, 140 mmol) under stirring at 0° C. The mixture was stirred for 3.5 h at ambient temperature. The mixture was concentrated i.vac., the residue stirred with water, filtered off, washed with water and dried.

1. stirringThe mixture was stirred for 3.5 h at ambient temperature
2. concentrationThe mixture was concentrated i.vac
3. stirring, the residue stirred with water
4. filtrationfiltered off
5. washwashed with water
6. customdried