反应详情

A mixture of 4-hydroxy thiobenzamide (100 g, 0.653 mol) and ethyl 2-chloroacetoacetate (118.3 g, 0.719 mol) in denatured spirit (DNS) (500 mL) was heated at about 60° C. to 65° C. for about 2.5 hours. The reaction mixture was cooled to about 0° C. to 5° C. and stirred for about 1 hour at the same temperature. The solid obtained was filtered, washed with denatured spirit and dried to obtain the title compound. (Yield: 156 g, 90.7%)

1. temperaturewas heated at about 60° C. to 65° C. for about 2.5 hours
2. temperatureThe reaction mixture was cooled to about 0° C. to 5° C.
3. customThe solid obtained
4. filtrationwas filtered
5. washwashed with denatured spirit
6. customdried