N-(3-(4-(1H-indazol-5-ylamino)-6-(2-methoxyethoxy) quinazolin-2-yl)phenyl)butyramide hydrochloride → HCID 25012250, compound

HRID 1407029Notes

Reaction equation

HRID 1407029 reaction equation
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][O:25][CH3:26])[CH:20]=4)[N:15]=[C:14]([C:27]4[CH:28]=[C:29]([NH:33][C:34](=[O:38])[CH2:35][CH2:36][CH3:37])[CH:30]=[CH:31][CH:32]=4)[N:13]=3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1>Cl>[NH:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][O:25][CH3:26])[CH:20]=4)[N:15]=[C:14]([C:27]4[CH:28]=[C:29]([NH:33][C:34](=[O:38])[CH2:35][CH2:36][CH3:37])[CH:30]=[CH:31][CH:32]=4)[N:13]=3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1

Participants

3

Reactant 1

HCID 66826667N-(3-(4-(1H-indazol-5-ylamino)-6-(2-methoxyethoxy) quinazolin-2-yl)phenyl)butyramide hydrochloride

Product 1

HCID 25012250HCID 25012250, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The purified solid was taken up in HCl (4M in 1,4 dioxane, 30 mL) and stirred at RT for 4.5 h. The volatiles were removed in vacuo and the residue was triturated with Et2O to give N-(3-(4-(1H-indazol-5-ylamino)-6-(2-methoxyethoxy)quinazolin-2-yl)phenyl)butyramide hydrochloride (0.091 g, 0.171 mmol, 55% over two steps). MS 497 (M+1). HPLC retention time 5.547 mins.

Workup

  1. customThe volatiles were removed in vacuo
  2. customthe residue was triturated with Et2O

Sources & evidence

ORD record
ord-00b31608f343484b8953e7eff28e53d8
Source dataset
uspto-grants-2014_12
Patent number
US08916576B2

Reaction notes

Loading…