HCID 86691682, compound → HCID 86691684, compound

HRID 1407046Notes

Reaction equation

HRID 1407046 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([NH:11][C:12]3[N:17]=[C:16]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])[N:15]=[C:14]([NH:24][C:25]4[CH:46]=[CH:45][C:28]([C:29]([NH:31][CH2:32][C:33]([CH3:44])([CH3:43])[CH2:34][NH:35]C(=O)OC(C)(C)C)=[O:30])=[CH:27][C:26]=4[F:47])[N:13]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>Cl.O1CCOCC1>[NH2:35][CH2:34][C:33]([CH3:44])([CH3:43])[CH2:32][NH:31][C:29](=[O:30])[C:28]1[CH:45]=[CH:46][C:25]([NH:24][C:14]2[N:13]=[C:12]([NH:11][C:8]3([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)[CH2:10][CH2:9]3)[N:17]=[C:16]([O:18][CH2:19][C:20]([F:22])([F:23])[F:21])[N:15]=2)=[C:26]([F:47])[CH:27]=1

Participants

4

Reactant 1

HCID 86691682HCID 86691682, compound

Product 1

HCID 86691684HCID 86691684, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-butyl 3-(4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-3-fluorobenzamido)-2,2-dimethylpropylcarbamate (270 mg, 0.40 mmol) was dissolved in 4 M HCl in dioxane (5 mL) solution. After being stirred at room temperature for 3 hours, the mixture was concentrated to give N-(3-amino-2,2-dimethylpropyl)-4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-3-fluorobenzamide as crude product.

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-fa5f6137ef1a42ba81a8094c71cbe8b8
Source dataset
uspto-grants-2014_12
Patent number
US08916702B2

Reaction notes

Loading…