反应详情

To an ice-cold solution of methyl O-benzyl-N-(tert-butoxycarbonyl)homoserinate (6 g, 18.6 mmol) in absolute ethanol (100 mL) is added sodium borohydride (2.8 g, 74.2 mmol), and the reaction is refluxed 2 h. The solution is cooled, excess saturated potassium carbonate added, and stirred 16 h at room temperature. The ethanol is removed under reduced pressure, and the aqueous solution is extracted with chloroform. The organic layer is washed with saturated sodium bicarbonate, saturated sodium sulfate, dried (magnesium sulfate), filtered, and concentrated under reduced pressure to give the title compound. ESI MS m/z 296.2 [M+H]+.

1. temperaturethe reaction is refluxed 2 h
2. temperatureThe solution is cooled
3. customThe ethanol is removed under reduced pressure
4. extractionthe aqueous solution is extracted with chloroform
5. washThe organic layer is washed with saturated sodium bicarbonate, saturated sodium sulfate
6. dry with materialdried (magnesium sulfate)
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure