Hydrochloric Acid → 2-Amino-4-(benzyloxy)butan-1-ol Hydrochloride

HRID 14079Notes

Reaction equation

HRID 14079 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][CH:11]([NH:14]C(=O)OC(C)(C)C)[CH2:12][OH:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:22]>O1CCOCC1>[ClH:22].[NH2:14][CH:11]([CH2:10][CH2:9][O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:12][OH:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21087273tert-Butyl 3-(benzyloxy)-1-(hydroxymethyl)propylcarbamate

Product 1

HCID 210854242-Amino-4-(benzyloxy)butan-1-ol Hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 3-(benzyloxy)-1-(hydroxymethyl)propylcarbamate (5 g, 17 mmol) is dissolved in 4 N hydrochloric acid in dioxane (21 mL) and stirred for 3 h at room temperature. The solution is concentrated under reduced pressure to give the title compound in pure form. ESI MS m/z 196.1 [M+H]+.

Workup

  1. concentrationThe solution is concentrated under reduced pressure

Sources & evidence

ORD record
ord-54f0530377d64b6180026ed173adc358
Source dataset
uspto-grants-2010_06
Patent number
US07727997B2

Reaction notes

Loading…