反应详情

Into a 100-mL round bottom flask, was placed a solution of N-(3-(trifluoromethyl)benzyl)-2-(2-nitrophenyl)isonicotinamide (350 mg, 0.87 mmol, 1.00 equiv) in ethanol/H2O (1/1) (30 mL), iron (489 mg, 8.73 mmol, 10.00 equiv), and acetic acid (0.1 mL). The resulting solution was heated to reflux for 0.5 h. The solids were filtered out. The resulting solution was extracted with of ethyl acetate and the organic layers combined and dried over magnesium sulfate. The solids were filtered out. The resulting mixture was concentrated under vacuum. The product was obtained as 260 mg (80%) of a yellow solid.

1. customInto a 100-mL round bottom flask, was placed
2. temperatureThe resulting solution was heated
3. temperatureto reflux for 0.5 h
4. filtrationThe solids were filtered out
5. extractionThe resulting solution was extracted with of ethyl acetate
6. dry with materialdried over magnesium sulfate
7. filtrationThe solids were filtered out
8. concentrationThe resulting mixture was concentrated under vacuum