N-Methylpropylamine → N1-methyl-N3-(4-(methyl(propyl)amino)-2-(4-((3-(trifluoromethyl)benzyl) carbamoyl)pyridin-2-yl)phenyl)-N-(2-morpholinoethyl)isophthalamide

HRID 1408178Notes

Reaction equation

HRID 1408178 reaction equation
[CH2:1]([N:3]([CH2:51][CH3:52])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:30])[C:12]2[CH:29]=[CH:28][CH:27]=[C:14]([C:15]([N:17]([CH3:26])[CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[O:16])[CH:13]=2)=[C:6]([C:31]2[CH:36]=[C:35]([C:37](=[O:50])[NH:38][CH2:39][C:40]3[CH:45]=[CH:44][CH:43]=[C:42]([C:46]([F:49])([F:48])[F:47])[CH:41]=3)[CH:34]=[CH:33][N:32]=2)[CH:5]=1)C.[CH3:53]NCCC>>[CH3:26][N:17]([CH2:18][CH2:19][N:20]1[CH2:21][CH2:22][O:23][CH2:24][CH2:25]1)[C:15](=[O:16])[C:14]1[CH:27]=[CH:28][CH:29]=[C:12]([C:11]([NH:10][C:7]2[CH:8]=[CH:9][C:4]([N:3]([CH3:1])[CH2:51][CH2:52][CH3:53])=[CH:5][C:6]=2[C:31]2[CH:36]=[C:35]([C:37](=[O:50])[NH:38][CH2:39][C:40]3[CH:45]=[CH:44][CH:43]=[C:42]([C:46]([F:49])([F:47])[F:48])[CH:41]=3)[CH:34]=[CH:33][N:32]=2)=[O:30])[CH:13]=1

Participants

3

Reactant 2

HCID 12315N-MethylpropylamineHCID 56952022N1-(4-(diethylamino)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)-N3-methyl-N3-(2-morpholinoethyl)isophthalamide

Product 1

HCID 66588229N1-methyl-N3-(4-(methyl(propyl)amino)-2-(4-((3-(trifluoromethyl)benzyl) carbamoyl)pyridin-2-yl)phenyl)-N-(2-morpholinoethyl)isophthalamide

Procedure

This compound was prepared according to the procedure described for the synthesis of N1-(4-(diethylamino)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)-N3-methyl-N3-(2-morpholinoethyl)isophthalamide 25, using N-methylpropan-1-amine in place of diethylamine. MS (ES, m/z): 717.3 [M+H]+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-ce070154d4d74fbf9a5461a18e3748c2
Source dataset
uspto-grants-2014_12
Patent number
US08916569B2

Reaction notes

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