Hydrochloric Acid → (S)-N1-(2-(1,4-diazepan-1-yl)ethyl)-N3-(4-(diethylamino)-2-(4-((1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyridin-2-yl)phenyl)-N1-methylisophthalamide

HRID 1408207Notes

Reaction equation

HRID 1408207 reaction equation
[CH2:1]([N:3]([CH2:58][CH3:59])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:14]=[C:15]([CH:36]=[CH:37][CH:38]=2)[C:16]([N:18]([CH2:20][CH2:21][N:22]2[CH2:28][CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]2)[CH3:19])=[O:17])=[O:12])=[C:6]([C:39]2[CH:44]=[C:43]([C:45](=[O:57])[NH:46][C@@H:47]3[C:56]4[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=4)[CH2:50][CH2:49][CH2:48]3)[CH:42]=[CH:41][N:40]=2)[CH:5]=1)[CH3:2].Cl>O1CCOCC1>[N:22]1([CH2:21][CH2:20][N:18]([CH3:19])[C:16](=[O:17])[C:15]2[CH:36]=[CH:37][CH:38]=[C:13]([C:11]([NH:10][C:7]3[CH:8]=[CH:9][C:4]([N:3]([CH2:1][CH3:2])[CH2:58][CH3:59])=[CH:5][C:6]=3[C:39]3[CH:44]=[C:43]([C:45](=[O:57])[NH:46][C@@H:47]4[C:56]5[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=5)[CH2:50][CH2:49][CH2:48]4)[CH:42]=[CH:41][N:40]=3)=[O:12])[CH:14]=2)[CH2:28][CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68087739(S)-tert-butyl 4-(2-(3-((4-(diethylamino)-2-(4-((1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl) pyridin-2-yl)phenyl)carbamoyl)-N-methylbenzamido)ethyl)-1,4-diazepane-1-carboxylate

Product 1

HCID 67516512(S)-N1-(2-(1,4-diazepan-1-yl)ethyl)-N3-(4-(diethylamino)-2-(4-((1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyridin-2-yl)phenyl)-N1-methylisophthalamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To (S)-tert-butyl 4-(2-(3-((4-(diethylamino)-2-(4-((1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyridin-2-yl)phenyl)carbamoyl)-N-methylbenzamido)ethyl)-1,4-diazepane-1-carboxylate was added 4M HCl in dioxane (3 mL). The mixture was stirred at room temperature for 2 h, concentrated to give a light yellow solid which was used without further purification.

Workup

  1. concentrationconcentrated
  2. customto give a light yellow solid which
  3. customwas used without further purification

Sources & evidence

ORD record
ord-877f631a232e40ebb504c288444ff4ec
Source dataset
uspto-grants-2014_12
Patent number
US08916569B2

Reaction notes

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