Hydrochloric Acid → HCID 86706007, compound

HRID 1408258Notes

Reaction equation

HRID 1408258 reaction equation
[CH2:1]([N:3]([CH2:65][CH3:66])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:14]=[C:15]([C:19](=[O:45])[N:20]([CH3:44])[CH2:21][CH2:22][N:23]([CH3:43])[CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][CH2:30][CH2:31][O:32][CH2:33][CH2:34][NH:35]C(=O)OC(C)(C)C)[CH:16]=[CH:17][CH:18]=2)=[O:12])=[C:6]([C:46]2[CH:51]=[C:50]([C:52](=[O:64])[NH:53][C@@H:54]3[C:63]4[C:58](=[CH:59][CH:60]=[CH:61][CH:62]=4)[CH2:57][CH2:56][CH2:55]3)[CH:49]=[CH:48][N:47]=2)[CH:5]=1)[CH3:2].[ClH:67]>O1CCOCC1>[ClH:67].[ClH:67].[ClH:67].[ClH:67].[NH2:35][CH2:34][CH2:33][O:32][CH2:31][CH2:30][O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][N:23]([CH3:43])[CH2:22][CH2:21][N:20]([CH3:44])[C:19](=[O:45])[C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([C:11]([NH:10][C:7]2[CH:8]=[CH:9][C:4]([N:3]([CH2:1][CH3:2])[CH2:65][CH3:66])=[CH:5][C:6]=2[C:46]2[CH:51]=[C:50]([C:52](=[O:64])[NH:53][C@@H:54]3[C:63]4[C:58](=[CH:59][CH:60]=[CH:61][CH:62]=4)[CH2:57][CH2:56][CH2:55]3)[CH:49]=[CH:48][N:47]=2)=[O:12])[CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86706008HCID 86706008, compound

Product 1

HCID 86706007HCID 86706007, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(S)-tert-Butyl 1-(3-(4-(diethylamino)-2-(4-(1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyridin-2-yl)phenylcarbamoyl)phenyl)-2,5-dimethyl-1-oxo-8,11,14-trioxa-2,5-diazahexadecan-16-ylcarbamate Example 339 (1.08 g, 1.23 mmol) and hydrochloric acid in dioxane (4N, 20 mL) were stirred for 4 hours at room temperature and then evaporated to dryness to give the intermediate (S)—N1-(14-amino-3-methyl-6,9,12-trioxa-3-azatetradecyl)-N3-(4-(diethylamino)-2-(4-(1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyridin-2-yl)phenyl)-N1-methylisophthalamide tetrahydrochloride 340a as a foam (1.2 g, quantitative); MS (ES, m/z): 808 [M+H]+.

Workup

  1. customwere stirred for 4 hours at room temperature
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-8d7d9d6161a24bf280e5c2509539e78f
Source dataset
uspto-grants-2014_12
Patent number
US08916569B2

Reaction notes

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