Trifluoroacetic acid → HCID 59484880, compound

HRID 1408398Notes

Reaction equation

HRID 1408398 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][C:9]2[CH:10]=[C:11]([C:15]3[N:20]=[CH:19][C:18](/[CH:21]=[CH:22]\[CH2:23][NH:24]C(=O)OC(C)(C)C)=[CH:17][N:16]=3)[CH:12]=[CH:13][CH:14]=2)[N:6]=[C:5]([C:32]2[CH:37]=[C:36]([F:38])[C:35]([F:39])=[C:34]([F:40])[CH:33]=2)[CH:4]=[CH:3]1.FC(F)(F)C(O)=O>ClCCl>[NH2:24][CH2:23]/[CH:22]=[CH:21]/[C:18]1[CH:17]=[N:16][C:15]([C:11]2[CH:10]=[C:9]([CH:14]=[CH:13][CH:12]=2)[CH2:8][N:7]2[C:2](=[O:1])[CH:3]=[CH:4][C:5]([C:32]3[CH:37]=[C:36]([F:38])[C:35]([F:39])=[C:34]([F:40])[CH:33]=3)=[N:6]2)=[N:20][CH:19]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86645315HCID 86645315, compound

Product 1

HCID 59484880HCID 59484880, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

48.3 28 mg (0.051 mmol) of tert-butyl [(Z)-3-(2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yl)allyl]carbamate are dissolved in 4 ml of dichloromethane, and 79 μl (1.02 mmol) of trifluoroacetic acid are added. The reaction mixture is stirred at room temperature for 15 h and evaporated. The residue is purified by means of preparative HPLC; yield: 11 mg of “A284” trifluoroacetate; HPLC: Rt=2.64 min (method C); LC-MS: 450 (M+H).

Workup

  1. customevaporated
  2. customThe residue is purified by means of preparative HPLC

Sources & evidence

ORD record
ord-86f6d249d9014cfcac8a27d72404853c
Source dataset
uspto-grants-2014_12
Patent number
US08921357B2

Reaction notes

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