反应详情

To a solution of methyl N-[[2-chloro-5-[3-(dimethylamino)-1-oxo-2-propen-1-yl]phenyl]methyl]carbamate (i.e. the product of Step A) (10 g, 33.78 mmol) in methanol (100 mL) was added hydrazine hydrate (1.08 mL, 33.78 mmol) and the reaction mixture was stirred at ambient temperature for 2 days. After TLC analysis (10% MeOH/CHCl3) showed completion of the reaction, the reaction mixture was filtered was filtered. The resultant solid residue was washed with methanol and dried under vacuum to give the title compound (4 g, 48% yield) as solid.

1. customcompletion of the reaction
2. filtrationthe reaction mixture was filtered
3. filtrationwas filtered
4. washThe resultant solid residue was washed with methanol
5. customdried under vacuum