2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine → HCID 46202650, compound

HRID 1408437Notes

Reaction equation

HRID 1408437 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:5]=[C:4]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:3]=1.[NH2:20][C:21]1[CH:26]=[CH:25][C:24](B2OC(C)(C)C(C)(C)O2)=[CH:23][N:22]=1>C(Cl)Cl.CO>[O:17]1[CH2:18][CH2:19][N:14]([C:4]2[N:5]=[C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)[N:7]=[C:2]([C:24]3[CH:25]=[CH:26][C:21]([NH2:20])=[N:22][CH:23]=3)[N:3]=2)[CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 2249672-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazineHCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

Product 1

HCID 46202650HCID 46202650, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Following the general procedure A, 4,4′-(6-chloro-1,3,5-triazine-2,4-diyl)dimorpholine was coupled with 2-aminopyridine-5-boronic acid pinacol ester with the reaction time of 15 h. Chromatography (methylene chloride/methanol 97:3) gave 69% of the title compound as a light yellow solid.

Sources & evidence

ORD record
ord-a7928f8ea5994e2a9ce65ab086874272
Source dataset
uspto-grants-2014_12
Patent number
US08921361B2

Reaction notes

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